Anti-Inflammatory Effects of Herbal-Derived Factors are Mediated By Down Regulation of Pro-Inflammatory Cytokines

محتوى المقالة الرئيسي

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منشور أيلول 13, 2010
Bahaa Hadieh Omar Said Mahmoud Masalh Basheer Abo Farkh Alaa Abo Mokh Bashar Saad

الملخص

The aim of the present in vitro study is to evaluate the role of pro-inflammatory
cytokines tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6) in the observed
anti-inflammatory effects of Hypericum triquetrifolium and Peganum harmale.
Therefore, water extracts from the aerial parts of the two plants were tested for their
anti-inflammatory effects in vitro using cells from the human monocyte cell line
THP-1. Anti-inflammatory effects were assessed by measuring the levels of
secretory proteins and mRNA of TNF-α and IL-6 production of LPS-activated THP1 cells. Cells were treated with 5µg lipopolyssacharide/ml (LPS) in the absence and
presence of increasing concentrations of plant extracts. During the entire
experimental period, we used plant extracts concentrations (up to 250µg/ml) that had
no cytotoxicity as measured in MTT assay. Hypericum triquetrifolium extracts
totally reduced the LPS induced TNF-α expression and secretion. Peganum harmale
extracts inhibited the IL-6 production in a dose dependent manner reaching the
control levels of untreated cells at a concentration of 125 µg/ml. These results
demonstrate that the anti-inflammatory effects of the two plants are mediated
through the inhibition of the pro-inflammatory cytokines TNF-α and IL-6.

كيفية الاقتباس

Hadieh, B., Said, O., Masalh, M., Abo Farkh, B., Abo Mokh, A., & Saad, B. (2010). Anti-Inflammatory Effects of Herbal-Derived Factors are Mediated By Down Regulation of Pro-Inflammatory Cytokines. جامعة - أبحاث في العلوم التربوية والاجتماعية, 14, 1–12. استرجع في من https://ojs.qsm.ac.il/index.php/jamiaa/article/view/323

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بيانات التنزيل غير متوفرة بعد.
Abstract 35 | pdf (English) Downloads 21

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